Ex. 1 lays out the moves. In this instance, we’re playing an A9 phrase, though these sixths can be transposed to outline any dominant-9th chord. Hearing the root can help you place these intervals in their harmonic context. You’ll find roots lurking on strings 6 and 1, parallel with the opening major sixth. (That’s at the 5th fret, in this example.)
In bar 1, notice how the top voice is our pal, the 5-6-7-6 (E-F#-G-F#) line. From Chuck Berry to P-Funk, this series of notes has one mission—make the music groove. Notice how the suggested fingering keeps your 2nd digit on the fourth string, where it serves to guide you along the fretboard through the various moves.
In Ex. 2, we drape our flipped sixths across a V-IV-I progression. Soul-jazz guitarists from the ’60s and early ’70s—including Kenny Burrell, George Benson, and Grant Green—played similar phrases in uptown blues and funk tunes.